Scientific Context

All bacterial species share a common evolutionary history. However, depending on their lifestyle, their environment or on evolutionary conditions, bacteria can have very different genomic and transcriptomic structures. For instance, all endosymbionts present very compact genomes while « free » bacteria usually have much larger genomes, containing up to ten times as many genes.

Aevol is a simulation platform that allows to let populations of digital organisms evolve in different conditions and study experimentally the mechanisms responsible for the structuration of the genome and the transcriptome.

The Aevol Model

Aevol is a digital genetics model: populations of digital organisms are subjected to a process of selection and variation, which creates a Darwinian dynamics. By modifying the characteristics of selection (e.g. population size, type of environment, environmental variations) or variation (e.g. mutation rates, chromosomal rearrangement rates, types of rearrangements, horizontal transfer), one can study experimentally the impact of these parameters on the structure of the evolved organisms. In particular, since Aevol integrates a precise and realistic model of the genome, it allows for the study of structural variations of the genome (e.g. number of genes, synteny, proportion of coding sequences).

The simulation platform comes along with a set of tools for analysing phylogenies and measuring many characteristics of the organisms and populations along evolution.

An extension of the model (R-Aevol), integrates an explicit model of the regulation of gene expression, thus allowing for the study of the evolution of gene regulation networks.